Myocardial protection by brief ischemia in noncardiac tissue.

  title={Myocardial protection by brief ischemia in noncardiac tissue.},
  author={Ben C. G. Gho and Regien Geertruida Schoemaker and Mirella A van den Doel and Dirk J. Duncker and Pieter D. Verdouw},
  volume={94 9},
BACKGROUND Brief coronary artery occlusions (CAOs) protect both the artery's own perfusion territory ("myocardial preconditioning") and adjacent "virgin" myocardium. Whether ischemia in remote organs protects myocardium is unknown. We examined whether brief occlusion of the anterior mesenteric artery (MAO) or left renal artery (RAO) protects against myocardial infarction. METHODS AND RESULTS Area at risk (AR) and infarcted area (IA) were determined in anesthetized rats after 180 minutes of… CONTINUE READING
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