Myocardial protection by Na(+)-H+ exchange inhibition in ischemic, reperfused porcine hearts.

@article{Klein1995MyocardialPB,
  title={Myocardial protection by Na(+)-H+ exchange inhibition in ischemic, reperfused porcine hearts.},
  author={Hermann Hubert Klein and Sibylle Pich and Rainer Bohle and J{\"u}rgen Wollenweber and Klaus Nebendahl},
  journal={Circulation},
  year={1995},
  volume={92 4},
  pages={912-7}
}
BACKGROUND Studies in isolated myocytes and isolated heart preparations have suggested that Na(+)-H+ exchange is an important mechanism for myocardial ischemia-reperfusion injury. This study was undertaken to determine whether inhibition of Na(+)-H+ exchange limits infarct size and improves regional systolic shortening in regional ischemia and reperfusion in intact pigs. METHODS AND RESULTS The left anterior descending coronary artery was occluded in 18 anesthetized and thoracotomized pigs… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition.

The Journal of pharmacology and experimental therapeutics • 2005

Similar Papers

Loading similar papers…