Myocardial protection after monophosphoryl lipid A: studies of delayed anti-ischaemic properties in rabbit heart.

@article{Baxter1996MyocardialPA,
  title={Myocardial protection after monophosphoryl lipid A: studies of delayed anti-ischaemic properties in rabbit heart.},
  author={Gary F. Baxter and Richard W. Goodwin and Matthew J Wright and Marko Kerac and Richard John Heads and Derek M Yellon},
  journal={British journal of pharmacology},
  year={1996},
  volume={117 8},
  pages={1685-92}
}
1. Monophosphoryl lipid A (MLA) is a non-pyrogenic derivative of Salmonella lipopolysaccharide. Administration of this agent at high doses to rats and at low doses to dogs was previously shown to confer marked protection against ischaemia-reperfusion 24 h later, although the cellular mechanisms of this delayed protection are obscure. We hypothesized that MLA pretreatment causes the induction of the 70 kDa cytoprotective stress protein HSP70i in the myocardium. If this were the case, protection… CONTINUE READING

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