Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function.

@article{Pieroni2007MyocardialPO,
  title={Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function.},
  author={Maurizio Pieroni and Angelo Corti and Bruno Tota and Flavio Curnis and Tommaso Angelone and Barbara Colombo and Maria Carmela Cerra and Fulvio Bellocci and Filippo Crea and Attilio Maseri},
  journal={European heart journal},
  year={2007},
  volume={28 9},
  pages={1117-27}
}
AIMS High chromogranin-A (CgA) levels were observed in patients with heart failure but its source remained uncertain. We evaluated whether CgA is produced by myocardium and might affect myocardial function. METHODS AND RESULTS We measured plasma CgA levels and performed immunohistochemistry with anti-CgA antibodies on myocardial biopsies in 40 patients with dilated cardiomyopathy (DCM) and 20 patients with hypertrophic cardiomyopathy (HCM). Surgical myocardial specimens from DCM and HCM… CONTINUE READING

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