Myocardial matrix metalloproteinase-2: inside out and upside down.

  title={Myocardial matrix metalloproteinase-2: inside out and upside down.},
  author={Ashley Decoux and Merry L Lindsey and Francisco J. Villarreal and Ricardo A. Garcia and Richard Schulz},
  journal={Journal of molecular and cellular cardiology},
Since their inaugural discovery in the early 1960s, matrix metalloproteinases (MMPs) have been shown to mediate multiple physiological and pathological processes. In addition to their canonical function in extracellular matrix (ECM) remodeling, research in the last decade has highlighted new MMP functions, including proteolysis of novel substrates beyond ECM proteins, MMP localization to subcellular organelles, and proteolysis of susceptible intracellular proteins in those subcellular… CONTINUE READING
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