Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits.

@article{Divald2010MyocardialIP,
  title={Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits.},
  author={Andras Divald and Shaye Kivity and Ping Wang and Edith Hochhauser and Beth Roberts and Saul Teichberg and Aldrin V Gomes and Saul R. Powell},
  journal={Circulation research},
  year={2010},
  volume={106 12},
  pages={1829-38}
}
RATIONALE The ubiquitin proteasome system (UPS) becomes dysfunctional as a result of ischemia/reperfusion (I/R), which may lead to dysregulation of signaling pathways. Ischemic preconditioning (IPC) may prevent dysregulation by preventing UPS dysfunction through inhibition of oxidative damage. OBJECTIVE Examine the hypothesis that early IPC preserves postischemic UPS function thus facilitating prosurvival signaling events. METHODS AND RESULTS I/R decreased proteasome chymotryptic activity… CONTINUE READING
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