Myocardial ischemia and reperfusion injury.

@article{Buja2005MyocardialIA,
  title={Myocardial ischemia and reperfusion injury.},
  author={Louis Maximilian Buja},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={2005},
  volume={14 4},
  pages={
          170-5
        }
}
  • L. Buja
  • Published 2005
  • Medicine
  • Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult. Myocardial ischemia results in a characteristic pattern of metabolic and ultrastructural changes that lead to irreversible injury. Recent studies have explored the relationship of myocardial ischemic… Expand
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Myocardial ischemia-reperfusion is the leading cause for the events of cardiovascular disease, and is considered as a major contributor to the morbidity and mortality associated with coronaryExpand
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TLDR
Progress in understanding the pathobiology of myocardial ischemic injury is leading to new therapeutic approaches to combine with established approaches for reperfusion and salvage ofMyocardium. Expand
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TLDR
Mechanisms of cardiac ischemia reperfusion injury are described followed by a discussion of how pressure/mechanical stress modulates endogenous cardiotoxic and cardioprotective mechanisms to ultimately exacerbate ischemic reperfusions injury. Expand
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  • L. Buja, P. Weerasinghe
  • Medicine
  • Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • 2010
TLDR
A model of myocardial ischemic and reperfusion injury is proposed involving the potential expression of apoptotic and oncotic pathways in the same perturbed cardiomyocytes, and promising new cardioprotective strategies for reducing lethal reperfusions injury are discussed. Expand
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TLDR
Mechanisms of cardiac ischemia reperfusion injury are described followed by a discussion of how pressure/mechanical stress modulates endogenous cardiotoxic and cardioprotective mechanisms to ultimately exacerbate ischemic-reperfused injury. Expand
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TLDR
Experimental and clinical data indicate that the recovery of systolic and diastolic function and the reduction in overall mortality are more favourably influenced by early coronary blood flow restoration. Expand
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The literature regarding the pathophysiology of myocardial IRI is explored, focusing on the possible role of the calpain system, oxidative-nitrosative stress, and matrix metalloproteinases and aiming to foster knowledge of IRI pathophysiological mechanisms also in terms of medicolegal understanding of sudden deaths following AMI. Expand
Symposium Paper Unresolved issues in myocardial reperfusion injury
TLDR
A model of myocardial ischemic and reperfusion injury is proposed involving the potential expression of apoptotic and oncotic pathways in the same perturbed cardiomyocytes, and promising new cardioprotective strategies for reducing lethal reperfusions injury are discussed. Expand
THE PATHOLOGY OF MYOCARDIAL INFARCTION FOLLOWING CORONARY RECANALIZATION
Coronary artery thrombosis, due either fissuring or erosion of atherosclerotic plaque, is the usual cause of acute myocardial infarction (1) and results in a progressive increase of the infarct sizeExpand
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  • Medicine
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