Myocardial infarction is associated with Spl binding site polymorphism of collagen type 1A1 gene.

Abstract

OBJECTIVE Human atherosclerotic lesions contain collagen type I, which plays a pivotal role in atherosclerotic plaque stability. In contrast, the normal coronary arteries do not express this type of collagen. Data have shown that the collagen type 1A1 (COL1A1) gene Sp1 binding site (-1245 G/T) polymorphism is associated with disturbed collagen protein… (More)

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