Myocardial infarction and intramyocardial injection models in swine

  title={Myocardial infarction and intramyocardial injection models in swine},
  author={Frederic C McCall and Kartik S. Telukuntla and Vasileios Karantalis and Viky Y. Suncion and Alan W. Heldman and Muzammil Mushtaq and Adam Williams and Joshua M Hare},
  journal={Nature Protocols},
Sustainable and reproducible large animal models that closely replicate the clinical sequelae of myocardial infarction (MI) are important for the translation of basic science research into bedside medicine. Swine are well accepted by the scientific community for cardiovascular research, and they represent an established animal model for preclinical trials for US Food and Drug Administration (FDA) approval of novel therapies. Here we present a protocol for using porcine models of MI created with… CONTINUE READING
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