Myocardial hypertrophy and its role in heart failure with preserved ejection fraction.

@article{Heinzel2015MyocardialHA,
  title={Myocardial hypertrophy and its role in heart failure with preserved ejection fraction.},
  author={Frank Heinzel and Felix Hohendanner and Ge Jin and Simon Sedej and Frank T Edelmann},
  journal={Journal of applied physiology},
  year={2015},
  volume={119 10},
  pages={1233-42}
}
Left ventricular hypertrophy (LVH) is the most common myocardial structural abnormality associated with heart failure with preserved ejection fraction (HFpEF). LVH is driven by neurohumoral activation, increased mechanical load, and cytokines associated with arterial hypertension, chronic kidney disease, diabetes, and other comorbidities. Here we discuss the experimental and clinical evidence that links LVH to diastolic dysfunction and qualifies LVH as one diagnostic marker for HFpEF… CONTINUE READING