Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model.

@article{Metzsch2006MyocardialGR,
  title={Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model.},
  author={Carsten Metzsch and Qiuming Liao and Stig Steen and Lars Algotsson},
  journal={Acta anaesthesiologica Scandinavica},
  year={2006},
  volume={50 1},
  pages={99-107}
}
BACKGROUND To develop cardioprotection against peri-operative myocardial ischemia-reperfusion injury, we need animal models where the local metabolism and blood flow are studied concomitantly with the global circulatory consequences during regional coronary occlusion. METHODS In six anesthetized domestic pigs, the largest branch of the circumflex artery was occluded for 30 min. Microdialysate was sampled from the ischemic and non-ischemic myocardium along with continuous measurements of local… CONTINUE READING
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