Myocardial fibroblast-matrix interactions and potential therapeutic targets.

  title={Myocardial fibroblast-matrix interactions and potential therapeutic targets.},
  author={Edie C. Goldsmith and Amy Dodd Bradshaw and Michael R. Zile and Francis G. Spinale},
  journal={Journal of molecular and cellular cardiology},
The cardiac extracellular matrix (ECM) is a dynamic structure, adapting to physiological and pathological stresses placed on the myocardium. Deposition and organization of the matrix fall under the purview of cardiac fibroblasts. While often overlooked compared to myocytes, fibroblasts play a critical role in maintaining ECM homeostasis under normal conditions and in response to pathological stimuli assume an activated, myofibroblast phenotype associated with excessive collagen accumulation… CONTINUE READING

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