Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat.

@article{Abbate2006MyocardialEO,
  title={Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat.},
  author={Antonio Abbate and Susanna Scarpa and Daniele Santini and Jimena Palleiro and Fortunata Vasaturo and John Lester Miller and Celina Morales and George Wayne Vetrovec and Alfonso Baldi},
  journal={International journal of cardiology},
  year={2006},
  volume={111 3},
  pages={371-6}
}
BACKGROUND Apoptosis plays a major role in the transition to heart failure (HF) in systemic hypertension although the underlying mechanisms are still unclear. The aim of this study was to determine the relationship between apoptosis, left ventricular remodeling, heart failure and the myocyte expression of survivin, an inhibitor of apoptosis. METHODS Spontaneously hypertensive rats (SHR) were used as a model of hypertensive cardiopathy, and Wistar Kyoto Stars rats (WKY) were used as controls… CONTINUE READING
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