Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.

@article{Adams2007MyocardialEO,
  title={Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.},
  author={Volker Adams and Axel Linke and Ulrik Wisloff and Christian D{\"o}ring and Sandra Erbs and Nicolle Kraenkel and Christian C. Witt and Siegfried Labeit and Ursula Mueller-Werdan and Gerhard A. Schuler and Rainer Hambrecht},
  journal={Cardiovascular research},
  year={2007},
  volume={73 1},
  pages={
          120-9
        }
}
OBJECTIVE In chronic heart failure (CHF) the myocardial expression of the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha), which is thought to contribute to myocardial remodeling, was found to be increased. However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha. METHODS Rats underwent ligation of the left coronary artery to induce CHF or were sham-operated. The… CONTINUE READING

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