Myocardial effects of repetitive episodes of rapid ventricular pacing in conscious dogs: surgical creation, echocardiographic evaluation, and morphometric analysis.

@article{Burkett1994MyocardialEO,
  title={Myocardial effects of repetitive episodes of rapid ventricular pacing in conscious dogs: surgical creation, echocardiographic evaluation, and morphometric analysis.},
  author={Dennis E. Burkett and A A Seymour and David H. Knight and C E Rabon and V M Lanoce and A F Clemons and Francis G. Spinale},
  journal={Laboratory animal science},
  year={1994},
  volume={44 5},
  pages={453-61}
}
The interactions of the systemic and myocardial adaptations during and after rapid ventricular pacing, a model of heart failure, were assessed in conscious, unstressed dogs. Ultrasonic probes and vascular catheters were surgically implanted into dogs for measurements of blood flows and pressures during 3 weeks of pacing and after 2 months of recovery. Three weeks of tachycardia (260 beats/min) resulted in a marked reduction in hemodynamic parameters and left ventricular dilatation, with caudal… CONTINUE READING