Myocardial depressant effects of desflurane: mechanical and electrophysiologic actions in vitro.

@article{Park2007MyocardialDE,
  title={Myocardial depressant effects of desflurane: mechanical and electrophysiologic actions in vitro.},
  author={Wyun Kon Park and Myung Hee Kim and Duck Sun Ahn and Jee Eun Chae and Young Seok Jee and Namsik Chung and Carl Lynch},
  journal={Anesthesiology},
  year={2007},
  volume={106 5},
  pages={956-66}
}
BACKGROUND The authors determined whether desflurane altered myocardial excitation-contraction coupling and electrophysiologic behavior in the same manner as isoflurane and sevoflurane. METHODS The effects of desflurane on isometric force in guinea pig ventricular papillary muscles were studied in modified standard and in 26 mM K(+) Tyrode solution with 0.1 microm isoproterenol. Desflurane effects on sarcoplasmic reticulum Ca(2+) release were also determined by examining its actions on rat… CONTINUE READING

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