Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.

  title={Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.},
  author={David Vancraeynest and Xavier Havaux and A C Pouleur and Agn{\`e}s Pasquet and Bernhard Gerber and Christophe Beauloye and Patrick Rafter and Luc Bertrand and Jean-Louis Vanoverschelde},
  journal={European heart journal},
  volume={27 2},
AIMS Ultrasound (US)-targeted microbubble destruction (UTMD) is a promising method for delivering genetic material to the heart. The aim of this study was: (i) to test whether colloid nanoparticles can be delivered to the rat myocardium using UTMD; and (ii) to determine whether tissue damage and contractile dysfunction occurs in hearts exposed to UTMD in vivo. METHODS AND RESULTS Hearts from anaesthetized rats were exposed to perfluorocarbon-enhanced sonicated dextrose albumin (PESDA) (at two… CONTINUE READING


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