Myocardial damage during ischaemia and reperfusion.

  title={Myocardial damage during ischaemia and reperfusion.},
  author={Massimo Chiariello and Giuseppe A Ambrosio},
  journal={Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology},
  volume={13 9},
Large quantities of oxygen free radicals can be generated on reperfusion of the ischemic myocardium. This phenomenon is probably responsible for a specific component of cell damage separate from ischemic injury and may blunt the beneficial effects of thrombolysis. Anti-free radical interventions may reduce the severity of this "reperfusion injury". However, reports of treatment failures indicate that reperfusion injury is a complex phenomenon, and suggest that the beneficial effects of… CONTINUE READING