Myocardial collagen turnover in hypertrophic cardiomyopathy.

  title={Myocardial collagen turnover in hypertrophic cardiomyopathy.},
  author={Raffaella Lombardi and Sandro Betocchi and Maria Angela Losi and Carlo Gabriele Tocchetti and Mariano Aversa and Marianna Miranda and Gianluigi D'Alessandro and Alessandra Cacace and Quirino Ciampi and Massimo Chiariello},
  volume={108 12},
BACKGROUND Myocardial interstitial fibrosis is a characteristic of hypertrophic cardiomyopathy (HCM). This study evaluates the collagen turnover in HCM and its impact on left ventricular (LV) diastolic function. METHODS AND RESULTS Thirty-six HCM patients and 14 sex- and age-matched controls were studied. Collagen turnover was assessed as follows. By radioimmunoassay, a byproduct of collagen III synthesis (PIIINP) and 3 peptides resulting from collagen I synthesis (PICP and PINP) and… CONTINUE READING


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