Myocardial cell death in human diabetes.

  title={Myocardial cell death in human diabetes.},
  author={Andrea Frustaci and Jan Kajstura and Cristina Chimenti and Igor Jakoniuk and Annarosa Leri and Attilio Maseri and Bernardo Nadal-Ginard and Piero Anversa},
  journal={Circulation research},
  volume={87 12},
The renin-angiotensin system is upregulated with diabetes, and this may contribute to the development of a dilated myopathy. Angiotensin II (Ang II) locally may lead to oxidative damage, activating cardiac cell death. Moreover, diabetes and hypertension could synergistically impair myocardial structure and function. Therefore, apoptosis and necrosis were measured in ventricular myocardial biopsies obtained from diabetic and diabetic-hypertensive patients. Accumulation of a marker of oxidative… CONTINUE READING
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