Myocardial beta-adrenoceptor down-regulation by norepinephrine is linked to reduced norepinephrine uptake activity.

@article{Dong1999MyocardialBD,
  title={Myocardial beta-adrenoceptor down-regulation by norepinephrine is linked to reduced norepinephrine uptake activity.},
  author={Erdan Dong and Atsuko Yatani and A. Madhan Mohan and Chang-seng Liang},
  journal={European journal of pharmacology},
  year={1999},
  volume={384 1},
  pages={17-24}
}
Chronic administration of norepinephrine for 8 weeks has been shown to reduce neuronal norepinephrine uptake activity and increase interstitial norepinephrine concentration in the heart. To determine whether the changes could lead to myocardial beta-adrenoceptor down-regulation or beta-adrenergic subsensitivity, we measured left ventricular contractile responses to dobutamine, myocardial beta-adrenoceptor density, beta subtype distribution, competitive inhibition agonist binding, and adenylyl… CONTINUE READING