Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.

@article{Rockman1996MyocardialBR,
  title={Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.},
  author={Howard A Rockman and Walter J Koch and Carmelo A. Milano and Robert J Lefkowitz},
  journal={Journal of molecular medicine},
  year={1996},
  volume={74 9},
  pages={489-95}
}
Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the section-adrenergic receptor (section-AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial… CONTINUE READING