Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.

@article{Kiuchi1993MyocardialBR,
  title={Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.},
  author={Kaname Kiuchi and Richard P. Shannon and Kazuo Komamura and Donald J. Cohen and Claudio Bianchi and Charles J. Homcy and Stephen F. Vatner and Dorothy E. Vatner},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 3},
  pages={907-14}
}
The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = 6), and 3-4 wk (n = 7). Left ventricular (LV) dP/dt was decreased (P < 0.0125) at 1 d, LV end-diastolic pressure and heart rate were increased (P < 0.0125) at 1 wk, but clinical signs of heart failure were only observed after 3-4 wk of pacing. Plasma norepinephrine rose (P < 0.0125) after 1 d of pacing, whereas LV norepinephrine was… CONTINUE READING

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