Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock.

@article{Jones1990MyocardialBA,
  title={Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock.},
  author={Shiloh B Jones and Fred D. Romano},
  journal={Circulatory shock},
  year={1990},
  volume={30 1},
  pages={51-61}
}
The present review is focused on one potential mechanism that may contribute to cardiac failure during developing septic shock. Evidence that sympathetic stimulation is intense in response to septic insult is presented and is related to possible desensitization of adrenergic mechanisms that mobilize cardiac reserve. Disruption of this signal transduction mechanism may be critical in that viable working myocardium becomes reduced as part of the tissue injury process during septic insult, thus… CONTINUE READING
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