Myocardial apoptosis associated with the expression of proinflammatory cytokines during the course of myocardial infarction

@article{Akasaka2006MyocardialAA,
  title={Myocardial apoptosis associated with the expression of proinflammatory cytokines during the course of myocardial infarction},
  author={Yoshikiyo Akasaka and Noriko Morimoto and Yukio Ishikawa and Kazuko Fujita and Kinji Ito and Masayo Kimura-Matsumoto and Shigeki Ishiguro and Hiroshi Morita and Yoshiro Kobayashi and Toshiharu Ishii},
  journal={Modern Pathology},
  year={2006},
  volume={19},
  pages={588-598}
}
To clarify the role of myocardial apoptosis associated with the expression of proinflammatory cytokines in human myocardial infarction (MI), we have analyzed the expression of apoptosis positive for single-stranded DNA (ss-DNA) antibody, tumor necrosis factor (TNF)-α, and interleukin (IL)-8 in 147 samples of infarcted myocardial tissue from 65 patients. ss-DNA-positive apoptotic nuclei were found mainly in cardiomyocytes in the border zones and granulation tissue cells in the infarct foci. The… CONTINUE READING

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