Myocardial aging--a stem cell problem.

  title={Myocardial aging--a stem cell problem.},
  author={Piero Anversa and Marcello Rota and Konrad Urbanek and Toru Hosoda and Edmund H. Sonnenblick and Annarosa Leri and Jan Kajstura and Roberto Bolli},
  journal={Basic research in cardiology},
  volume={100 6},
This review questions the old paradigm that describes the heart as a post-mitotic organ and introduces the notion of the heart as a self-renewing organ regulated by a compartment of multipotent cardiac stem cells (CSCs) capable of regenerating myocytes and coronary vessels throughout life. Because of this dramatic change in cardiac biology, the objective is… CONTINUE READING