Myocardial Structure and Function


Background. Studies done in potential donors for heart transplantation and in experimental animals have suggested that brain death can have major histopathological and functional effects on the myocardium. Methods and Results. We developed experimental models of brain death using dogs to study the hemodynamic and catecholamine changes, the extent of myocardial structural damage, and the recovery potential of donor hearts obtained from brain-dead donors. Brain death was caused by increasing the intracranial pressure (ICP) suddenly or gradually by injecting saline in an epidural Foley catheter. In a first series of experiments, dogs given a sudden rise in ICP (n=5) showed a hyperdynamic response and

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@inproceedings{Shivalkar2005MyocardialSA, title={Myocardial Structure and Function}, author={Bharati Shivalkar and Johan van Loon and Christiaan Plets}, year={2005} }