Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice.

@article{Jones2000MyocardialRI,
  title={Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice.},
  author={Steven P Jones and David Joseph Lefer},
  journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society},
  year={2000},
  volume={15},
  pages={303-308}
}
Myocardial ischemia-reperfusion injury involves activation of multiple cell types, including leukocytes and endothelial cells. The pursuant inflammation involves diminished nitric oxide production, influx of neutrophils, and myocardial cell injury. Gene-targeted animals provide important clues about the progression of this inflammatory cascade.