Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.

@article{Rentschler2012MyocardialNS,
  title={Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.},
  author={Stacey L Rentschler and Alberta H. Yen and Jia Jie Lu and Nataliya B. Petrenko and Min Min Lu and Lauren J. Manderfield and Vickas V. Patel and Glenn I. Fishman and Jonathan A. Epstein},
  journal={Circulation},
  year={2012},
  volume={126 9},
  pages={1058-66}
}
BACKGROUND Notch signaling has previously been shown to play an essential role in regulating cell fate decisions and differentiation during cardiogenesis in many systems including Drosophila, Xenopus, and mammals. We hypothesized that Notch may also be involved in directing the progressive lineage restriction of cardiomyocytes into specialized conduction cells. METHODS AND RESULTS In hearts where Notch signaling is activated within the myocardium from early development onward, Notch promotes… CONTINUE READING
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