Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy.

  title={Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy.},
  author={Francis G. Spinale and Chris Clayton and Ryuichi Tanaka and B M Fulbright and Rupak Mukherjee and Bradley A. Schulte and Fred A. Crawford and Michael R. Zile},
  journal={Journal of molecular and cellular cardiology},
  volume={24 3},
Na+,K(+)-ATPase is a major determinant of myocyte homeostasis and excitation-contraction. Cardiac glycosides such as digitalis and ouabain increase the inotropic state of the heart through the inhibition of Na+,K(+)-ATPase. While cardiac glycosides are commonly used in the setting of congestive heart failure, optimal therapy would depend upon an intact Na+,K(+)-ATPase system. Changes in Na+,K(+)-ATPase activity and glycoside receptor density with the development of cardiomyopathy have not been… CONTINUE READING
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