Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

Abstract

The use of anthracyclines such as doxorubicin (DOX) has improved outcome in cancer patients, yet associated risks of cardiomyopathy have limited their clinical application. DOX-associated cardiotoxicity is frequently irreversible and typically progresses to heart failure (HF) but our understanding of molecular mechanisms underlying this and essential for… (More)
DOI: 10.1038/cddis.2015.89

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Cite this paper

@inproceedings{RocaAlonso2015MyocardialMD, title={Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis}, author={Laura Roca-Alonso and Leandro Castellano and A. Mills and Anita Dabrowska and Markus Bernardus Sikkel and L. Pellegrino and J. Jacob and Adam Enver Frampton and James M Krell and Raoul Charles Coombes and Sian E Harding and Aaron R Lyon and Justin Stebbing}, booktitle={Cell Death and Disease}, year={2015} }