Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction.

  title={Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction.},
  author={Masaru Obokata and Yogesh N. V. Reddy and Vojtěch Melenovsk{\'y} and Garvan C Kane and Thomas P. Olson and Petr Jarolim and Barry A. Borlaug},
  journal={Journal of the American College of Cardiology},
  volume={72 1},
BACKGROUND Cardiac reserve is depressed in patients with heart failure and preserved ejection fraction (HFpEF). The mechanisms causing this are poorly understood. OBJECTIVES The authors hypothesized that myocardial injury might contribute to the hemodynamic derangements and cardiac reserve limitations that are present in HFpEF. Markers of cardiomyocyte injury, central hemodynamics, ventricular function, and determinants of cardiac oxygen supply-demand balance were measured. METHODS Subjects… CONTINUE READING


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