Myocardial Infarction and Functional Outcome Assessment in Pigs

  title={Myocardial Infarction and Functional Outcome Assessment in Pigs},
  author={Stefan Koudstaal and Sanne Johanna Jansen of Lorkeers and Johannes M. I. H. Gho and G. P. J. van Hout and Marlijn S. Jansen and Paul F. Gr{\"u}ndeman and G. Pasterkamp and Pieter A. F. M. Doevendans and Imo E. Hoefer and Steven A. J. Chamuleau},
  booktitle={Journal of visualized experiments : JoVE},
Introduction of newly discovered cardiovascular therapeutics into first-in-man trials depends on a strictly regulated ethical and legal roadmap. One important prerequisite is a good understanding of all safety and efficacy aspects obtained in a large animal model that validly reflect the human scenario of myocardial infarction (MI). Pigs are widely used in this regard since their cardiac size, hemodynamics, and coronary anatomy are close to that of humans. Here, we present an effective protocol… CONTINUE READING


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