Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis.

@article{Frunza2016MyocardialGE,
  title={Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis.},
  author={Olga Frunza and Ilaria Russo and Amit Saxena and Arti V. Shinde and Claudio Humeres and Waqas Hanif and Vikrant R Rai and Ya Su and Nikolaos G Frangogiannis},
  journal={The American journal of pathology},
  year={2016},
  volume={186 5},
  pages={1114-27}
}
The β-galactoside-binding animal lectin galectin-3 is predominantly expressed by activated macrophages and is a promising biomarker for patients with heart failure. Galectin-3 regulates inflammatory and fibrotic responses; however, its role in cardiac remodeling remains unclear. We hypothesized that galectin-3 may be up-regulated in the pressure-overloaded myocardium and regulate hypertrophy and fibrosis. In normal mouse myocardium, galectin-3 was constitutively expressed in macrophages and was… CONTINUE READING
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