Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

@article{Montaigne2014MyocardialCD,
  title={Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients},
  author={D. Montaigne and X. Mar{\'e}chal and A. Coisne and Nicolas Debry and T. Modine and G. Fayad and Charlotte Potelle and J. El Arid and S. Mouton and Y. Sebti and H. Duez and S. Preau and I. R{\'e}my-Jouet and F. Zerimech and M. Koussa and V. Richard and R. Nevi{\`e}re and J. Edm{\'e} and P. Lefebvre and B. Staels},
  journal={Circulation},
  year={2014},
  volume={130},
  pages={554–564}
}
Background— Obesity and diabetes mellitus are independently associated with the development of heart failure. In this study, we determined the respective effects of obesity, insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial function of the human myocardium before the onset of cardiomyopathy. Methods and Results— Right atrial myocardium was obtained from 141 consecutive patients presenting no sign of cardiomyopathy. We investigated ex vivo isometric… Expand

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