Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10

@inproceedings{Nogueira2012MyocardialCE,
  title={Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10},
  author={Luciana Gabriel Nogueira and Ronaldo Honorato Barros Santos and B{\'a}rbara Maria Ianni and Alfredo In{\'a}cio Fiorelli and Eliane Conti Mairena and Luiz Alberto Benvenuti and Amanda Farage Frade and Eduardo Ant{\^o}nio Donadi and Fabr{\'i}cio da Costa Dias and Bruno Saba and Hui-Tzu Lin Wang and Ab{\'i}lio Augusto Fragata and Marcelo Hamiltom Sampaio and M{\'a}rio Hiroyuki Hirata and P. Buck and Charles Mady and Edimar Alcides Bocchi and Noedir Ant{\^o}nio Groppo Stolf and Jorge Agle Kalil and Edecio Cunha-Neto},
  booktitle={PLoS neglected tropical diseases},
  year={2012}
}
BACKGROUND Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though the Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis, little is known about the factors controlling inflammatory cell migration to CCC myocardium. METHODS AND RESULTS Using confocal immunofluorescence and quantitative PCR, we studied cell surface staining and gene expression of… CONTINUE READING
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