Myocardial Akt activation and gender: increased nuclear activity in females versus males.

@article{CamperKirby2001MyocardialAA,
  title={Myocardial Akt activation and gender: increased nuclear activity in females versus males.},
  author={D Camper-Kirby and Sara Welch and Azida Walker and Isao Shiraishi and Kenneth D. R. Setchell and Ellen Schaefer and Jan Kajstura and Piero Anversa and Mark A Sussman},
  journal={Circulation research},
  year={2001},
  volume={88 10},
  pages={1020-7}
}
Cardiovascular disease risk is higher in men than women, but the basis for this discrepancy remains controversial. Estrogenic stimulation of the myocardium or isolated cardiomyocytes has been purported to exert multiple beneficial effects associated with inhibition of maladaptive responses to pathogenic insults. This report describes a significant difference between the sexes in myocardial activation of Akt, a protein kinase that regulates a broad range of physiological responses including… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 121 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Estrogen receptor a rapidly activates the IGF-1 receptor pathway

  • S Kahlert, S Nuedling, M van Eickels, H Vetter, R Meyer, C. Grohe
  • J Biol Chem
  • 2000

Membrane receptor estrogen engagement activates endothelial nitric oxide synthase via the PI 3K - Akt pathway in human endothelial cells

  • MP Haynes, D Sinha, +5 authors Bender
  • Circ Res
  • 2000

Similar Papers

Loading similar papers…