Myocardial Akt activation and gender: increased nuclear activity in females versus males.

  title={Myocardial Akt activation and gender: increased nuclear activity in females versus males.},
  author={D Camper-Kirby and Sara Welch and Azida Walker and Isao Shiraishi and Kenneth D. R. Setchell and Ellen Schaefer and Jan Kajstura and Piero Anversa and Mark A Sussman},
  journal={Circulation research},
  volume={88 10},
Cardiovascular disease risk is higher in men than women, but the basis for this discrepancy remains controversial. Estrogenic stimulation of the myocardium or isolated cardiomyocytes has been purported to exert multiple beneficial effects associated with inhibition of maladaptive responses to pathogenic insults. This report describes a significant difference between the sexes in myocardial activation of Akt, a protein kinase that regulates a broad range of physiological responses including… CONTINUE READING


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