Myoblasts transferred to the limbs of embryos are committed to specific fibre fates

@article{Dimario1993MyoblastsTT,
  title={Myoblasts transferred to the limbs of embryos are committed to specific fibre fates},
  author={Joseph X Dimario and Susan E. Fernyak and Frank E. Stockdale},
  journal={Nature},
  year={1993},
  volume={362},
  pages={165-167}
}
IN the limb bud of the 5-day-old avian embryo, when primary muscle fibre formation is beginning and before specific muscles appear, differences in the expression of fast and slow myosin heavy chain genes can be detected among primary fibres of the premuscle masses1,2. Myoblasts that form colonies of fibres of specific types can be isolated from these limb buds3. To assess the role of myoblast commitment in specifying fibre types during embryonic development, we cloned myoblasts of specific… CONTINUE READING

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