Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.

@article{Yates2014MyoblastsFI,
  title={Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.},
  author={Dustin T. Yates and Derek S Clarke and Antoni R. Macko and Miranda J. Anderson and Leslie A Shelton and Marie Nearing and Ronald E. Allen and Robert P. Rhoads and Sean W Limesand},
  journal={The Journal of physiology},
  year={2014},
  volume={592 14},
  pages={3113-25}
}
Intrauterine growth restriction (IUGR) reduces skeletal muscle mass in fetuses and offspring. Our objective was to determine whether myoblast dysfunction due to intrinsic cellular deficiencies or serum factors reduces myofibre hypertrophy in IUGR fetal sheep. At 134 days, IUGR fetuses weighed 67% less (P < 0.05) than controls and had smaller (P < 0.05) carcasses and semitendinosus myofibre areas. IUGR semitendinosus muscles had similar percentages of pax7-positive nuclei and pax7 mRNA but lower… CONTINUE READING
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