Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice

Abstract

Diabetes is associated with reduced expression of heme oxygenase-1 (HO-1), a heme-degrading enzyme with cytoprotective and proangiogenic properties. In myoblasts and muscle satellite cells HO-1 improves survival, proliferation and production of proangiogenic growth factors. Induction of HO-1 in injured tissues facilitates neovascularization, the process… (More)
DOI: 10.1186/s13287-015-0063-8

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