Myoblast-based gene therapies.

  title={Myoblast-based gene therapies.},
  author={T A Partridge and K. E. Davies},
  journal={British medical bulletin},
  volume={51 1},
Recent identification of the genetic causes of several neuromuscular disorders has aroused interest in gene therapy in skeletal muscle. The genetic constitution of skeletal muscle can be altered by a number of means. Myoblasts can be used to introduce new genes, endogenous or exogenous, into muscle fibres during growth and repair. DNA expression-plasmids can be directly transfected into a small proportion of muscle fibres, showing persistent expression despite their lack of genomic integration… CONTINUE READING
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