Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis.

@article{Chang2006MyobacteriumTI,
  title={Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis.},
  author={Jung-Su Chang and Jim F Huggett and Keertan Dheda and Louise U. Kim and Alimuddin M. Zumla and Graham A. W. Rook},
  journal={Journal of immunology},
  year={2006},
  volume={176 5},
  pages={3010-8}
}
Human and mouse studies indicate that TLRs are important in mycobacterial infections. We investigated TLR gene expression in fresh unstimulated blood and bronchoalveolar lavage from patients with pulmonary tuberculosis using a well-validated, real-time PCR. A human splice variant of TLR1, designated hsTLR1, was found in all donors tested. hsTLR1 mRNA lacks exon 2, which is a 77-bp region of the 5'-untranslated region, but contains the same coding sequence as TLR1. Compared with the matched… CONTINUE READING

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