MyoD or Myf-5 is required for the formation of skeletal muscle

@article{Rudnicki1993MyoDOM,
  title={MyoD or Myf-5 is required for the formation of skeletal muscle},
  author={M. Rudnicki and P. Schnegelsberg and R. Stead and T. Braun and H. Arnold and R. Jaenisch},
  journal={Cell},
  year={1993},
  volume={75},
  pages={1351-1359}
}
Mice carrying null mutations in the myogenic regulatory factors Myf-5 or MyoD have apparently normal skeletal muscle. To address whether these two factors functionally substitute for one another in myogenesis, mice carrying mutant Myf-5 and MyoD genes were interbred. While mice lacking both MyoD and Myf-5 were born alive, they were immobile and died soon after birth. Northern blot and S1 nuclease analyses indicated that Myf-5(-1-);MyoD(-1-) mice expressed no detectable skeletal muscle-specific… Expand
Targeted inactivation of myogenic factor genes reveals their role during mouse myogenesis: a review.
  • H. Arnold, T. Braun
  • Biology, Medicine
  • The International journal of developmental biology
  • 1996
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice.
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.
MyoD-expressing progenitors are essential for skeletal myogenesis and satellite cell development.
MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice.
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
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