MyoD is functionally linked to the silencing of a muscle-specific regulatory gene prior to skeletal myogenesis.

@article{Mal2003MyoDIF,
  title={MyoD is functionally linked to the silencing of a muscle-specific regulatory gene prior to skeletal myogenesis.},
  author={Asoke K. Mal and Marian L. Harter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={1735-9}
}
Most of the genes that are central to the process of skeletal muscle differentiation remain in a transcriptionally silent or "off" state until muscle cells (myoblasts) are induced to differentiate. Although the mechanisms that contribute to this phenomenon are still unclear, it is likely that histone deacetylases (HDACs), which play an important role in the repression of genes, are principally involved. Recent studies indicate that the initiator of the myogenic program, namely MyoD, can… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
MuscleAnatomy originated from biological processMyogenesis
MyoD is functionally linked to the silencing of a muscle - specific regulatory gene prior to skeletal myogenesis .
MyogenesisProcess involves geneMYOD1 wt Allele
MyoD is functionally linked to the silencing of a muscle - specific regulatory gene prior to skeletal myogenesis .
All Topics