MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice.

@article{Braun1994MyoDEM,
  title={MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice.},
  author={T. Braun and Eva Bober and Michael Rudnicki and Rudolf Jaenisch and Hans Henning Arnold},
  journal={Development},
  year={1994},
  volume={120 11},
  pages={3083-92}
}
The expression pattern of myogenic regulatory factors and myotome-specific contractile proteins was studied during embryonic development of Myf-5 mutant mice by in situ hybridization and immunohistochemistry. In contrast to somites in wild-type embryos, no expression of myogenin and Myf-6 (MRF4), or any other myotomal markers was detected in mutant animals at E9.0 and E10.0 indicating that Myf-5 plays a crucial role during this developmental period. Significantly, the onset of MyoD expression… CONTINUE READING
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