Mylotarg: antibody-targeted chemotherapy comes of age

@article{Sievers2001MylotargAC,
  title={Mylotarg: antibody-targeted chemotherapy comes of age},
  author={Eric L. Sievers and Michael L. Linenberger},
  journal={Current Opinion in Oncology},
  year={2001},
  volume={13},
  pages={522-527}
}
Mylotarg (gemtuzumab ozogamicin, CMA-676; Wyeth-Ayerst Laboratories, Philadelphia, PA) recently was approved by the US Food and Drug Administration for the treatment of patients with CD33-positive acute myeloid leukemia in first relapse, age 60 years or older, who are not considered candidates for other types of cytotoxic chemotherapy. In combined phase II studies of 142 patients with CD33-positive acute myeloid leukemia in first relapse, Mylotarg monotherapy was associated with a 30% overall… 

Gemtuzumab Ozogamicin (CMA-676, Mylotarg) for the treatment of CD33+ acute myeloid leukemia.

TLDR
Future phase III trials will show the most suitable place of GO in the treatment of AML, with the most frequent adverse effect observed is myelotoxicity, with prolonged neutropenia and thrombocytopenia.

Immunobiologic therapies for myelodysplastic syndrome.

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Gemtuzumab Ozogamicin

TLDR
Gemtuzumab ozogamicin is a valuable new treatment option for patients aged ≥60 years with CD33-positive AML in first relapse for whom other cytotoxic chemotherapy is not considered appropriate; patients with a first CR (CR1) of >12 months are likely to have the best outcome.

Gemtuzumab Ozogamicin (Mylotarg®) in Children with Refractory or Relapsed Acute Myeloid Leukemia

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Gemtuzumab ozogamicin therapy can induce blast reduction in children who have no further conventional treatment options and seems to be feasible for children with a sufficient general condition.

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TLDR
Clinical efficacy of GO is demonstrated in a subset of relapsed/refractory pediatric CD33(+) AML patients and suggests that intensive postremission therapy after remission induction by GO may result in durable responses in some patients, although follow-up is still short.

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TLDR
Data indicate that anti-CD20–based antibody-drug conjugates are effective antitumor agents when prepared with a stable, enzyme-cleavable peptide linkage to highly potent cytotoxic agents such as MMAE.

Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin in vitro: role of Chk1 and Chk2 phosphorylation and caspase 3.

TLDR
Investigation of the effects of GO on human myeloid leukemia lines of different French-American-British (FAB) types suggests that the different molecular pathways induced by the drug in vitro may reflect the variable response to GO obtained in vivo.

Targeted therapy for hematologic malignancies.

  • P. Kuriakose
  • Medicine, Biology
    Cancer control : journal of the Moffitt Cancer Center
  • 2005
TLDR
Targeted therapy of hematologic malignancies seems to be an effective and less toxic approach to the treatment of such disorders.
...

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