Myelopoietic response in tumour-bearing mice by an aggregated polymer isolated from Aspergillus oryzae.

@article{Justo2000MyelopoieticRI,
  title={Myelopoietic response in tumour-bearing mice by an aggregated polymer isolated from Aspergillus oryzae.},
  author={Giselle Zenker Justo and Nelson Dur{\'a}n and Mary Luci de Souza Queiroz},
  journal={European journal of pharmacology},
  year={2000},
  volume={388 3},
  pages={219-26}
}
The effects of magnesium ammonium phospholinoleate-palmitoleate anhydride (MAPA), a proteic aggregated polymer isolated from Aspergillus oryzae, on the growth and differentiation of granulocyte-macrophage progenitor cells (colony-forming unit-granulocyte-macrophage [CFU-GM]) in normal and Ehrlich ascites tumour-bearing mice were studied. Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with MAPA (0.5-10 mg/kg… CONTINUE READING