Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.

  title={Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.},
  author={John W. Chen and Michael O Breckwoldt and Elena Aikawa and Gloria Chiang and Ralph Weissleder},
  journal={Brain : a journal of neurology},
  volume={131 Pt 4},
Inflammatory demyelinating plaques are the pathologic hallmark of active multiple sclerosis and often precede clinical manifestations. Non-invasive early detection of active plaques would thus be crucial in establishing pre-symptomatic diagnosis and could lead to early preventive treatment strategies. Using murine experimental autoimmune encephalomyelitis as a model of multiple sclerosis, we demonstrate that a prototype paramagnetic myeloperoxidase (MPO) sensor can detect and confirm more… CONTINUE READING
31 Citations
48 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Imaging myeloperoxidase in mice using novel amplifiable paramagnetic substrates

  • JW Chen, M Querol Sans, AA JrBogdanov, R. Weissleder
  • Radiology
  • 2006
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…