Myeloperoxidase-mediated iodination by granulocytes. Intracellular site of operation and some regulating factors.

Abstract

The intracellular site of operation of the myeloperoxidase-H(2)O(2)-halide antibacterial system of granulocytes has been determined by utilizing measurements of the fixation of iodide to trichloracetic acid (TCA) precipitates of subcellular fractions, including intact phagocytic vesicles. Na(125)I was added to suspensions of guinea pig granulocytes in Krebs… (More)

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