Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion.

@article{Matthijsen2007MyeloperoxidaseIC,
  title={Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion.},
  author={Robert A. Matthijsen and Dennis Huugen and Nicole T. H. Hoebers and Bernard J. de Vries and Carine J. Peutz-Kootstra and Yasuaki Aratani and Mohamed R. Daha and Jan Willem Cohen Tervaert and Wim A. Buurman and Peter Heeringa},
  journal={The American journal of pathology},
  year={2007},
  volume={171 6},
  pages={
          1743-52
        }
}
In this study the role of myeloperoxidase (MPO) in a murine (C57BL/6) model of ischemia and reperfusion (I/R)-induced renal failure was investigated. The renal function after I/R was analyzed in MPO-deficient (Mpo(-/-)) mice and compared with wild-type (WT) controls. A significant reduction in renal function loss (blood urea nitrogen) was observed after 24 hours of reperfusion of ischemically damaged kidneys in Mpo(-/-) mice compared with I/R WT controls (I/R Mpo(-/-) = 31.3 +/- 1.7 mmol/L… CONTINUE READING
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